The cranial sensory nervous system: specification of sensory progenitors and placodes
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منابع مشابه
The peripheral sensory nervous system in the vertebrate head: a gene regulatory perspective.
In the vertebrate head, crucial parts of the sense organs and sensory ganglia develop from special regions, the cranial placodes. Despite their cellular and functional diversity, they arise from a common field of multipotent progenitors and acquire distinct identity later under the influence of local signalling. Here we present the gene regulatory network that summarises our current understandi...
متن کاملThe preplacodal region: an ectodermal domain with multipotential progenitors that contribute to sense organs and cranial sensory ganglia.
The otic primordium belongs to a group of related structures, the sensory placodes that contribute to the paired sense organs - ear, eye and olfactory epithelium - and to the distal parts of the cranial sensory ganglia. Recent evidence suggests that despite their diversity, all placodes share a common developmental origin and a common molecular mechanism which initiates their formation. At the ...
متن کاملClonal analyses in the anterior pre-placodal region: implications for the early lineage bias of placodal progenitors.
Cranial ectodermal placodes, a vertebrate innovation, contribute to the adenohypophysis and peripheral nervous system of the head, including the paired sense organs (eyes, nose, ears) and sensory ganglia of the Vth, VIIth, IXth and Xth cranial nerves. Fate-maps of groups of cells in amphibians, teleosts and amniotes have demonstrated that all placodes have a common origin in a horseshoe shaped ...
متن کاملDirectional cell movements downstream of Gbx2 and Otx2 control the assembly of sensory placodes
Cranial placodes contribute to sensory structures including the inner ear, the lens and olfactory epithelium and the neurons of the cranial sensory ganglia. At neurula stages, placode precursors are interspersed in the ectoderm surrounding the anterior neural plate before segregating into distinct placodes by as yet unknown mechanisms. Here, we perform live imaging to follow placode progenitors...
متن کاملSpecification of functional cranial placode derivatives from human pluripotent stem cells.
Cranial placodes are embryonic structures essential for sensory and endocrine organ development. Human placode development has remained largely inaccessible despite the serious medical conditions caused by the dysfunction of placode-derived tissues. Here, we demonstrate the efficient derivation of cranial placodes from human pluripotent stem cells. Timed removal of the BMP inhibitor Noggin, a c...
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